Genes, Free Full-Text
Por um escritor misterioso
Last updated 19 março 2025

KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation. KMT2A has a crucial role in gene expression, thus it is associated to pathological conditions when found mutated. KMT2A germinal mutations are associated to Wiedemann–Steiner syndrome and also in patients with initial clinical diagnosis of several other chromatinopathies (i.e., Coffin–Siris syndromes, Kabuki syndrome, Cornelia De Lange syndrome, Rubinstein–Taybi syndrome), sharing an overlapping phenotype. On the other hand, KMT2A somatic mutations have been reported in several tumors, mainly blood malignancies. Due to its evolutionary conservation, the role of KMT2A in embryonic development, hematopoiesis and neurodevelopment has been explored in different animal models, and in recent decades, epigenetic treatments for disorders linked to KMT2A dysfunction have been extensively investigated. To note, pharmaceutical compounds acting on tumors characterized by KMT2A mutations have been formulated, and even nutritional interventions for chromatinopathies have become the object of study due to the role of microbiota in epigenetic regulation.

Genes, Free Full-Text

Ivar Text Font Get File - Colaboratory
Genes & Genomics

IJMS, Free Full-Text

Inferring gene expression from cell-free DNA fragmentation

Genetics: From Genes to Genomes
The Journal of Gene Medicine - Wiley Online Library

genesis - Wiley Online Library

BioCyc Pathway/Genome Database Collection

Gene Definition, Structure & Components - Video & Lesson
Hartwell Genetics From Genes To Genomes 4th Txtbk : Free Download

Inferring Phylogenies Felsenstein Pdf Download - Colaboratory
Recomendado para você
-
Genes, Free Full-Text19 março 2025
-
Rubinstein-Taybi Syndrome: A Complete Overview — DermNet19 março 2025
-
Rubinstein Taybi syndrome causes, symptoms, diagnosis, treatment & prognosis19 março 2025
-
Figure 1. [Facial appearance of a girl age 11 years with FHS (SRCAP pathogenic variant p.Arg2444Ter)]. - GeneReviews® - NCBI Bookshelf19 março 2025
-
Extending the clinical and genetic spectrum of ARID2 related intellectual disability. A case series of 7 patients - ScienceDirect19 março 2025
-
PDF) An unusual presentation of Rubinstein-Taybi Syndrome with bilateral postaxial polydactyly Corresponding author19 março 2025
-
Clinical and mutational spectrum in Korean patients with Rubinstein–Taybi syndrome: The spectrum of brain MRI abnormalities - ScienceDirect19 março 2025
-
Beckwith-Wiedemann Syndrome - GeneReviews® - NCBI Bookshelf19 março 2025
-
Rubinstein-Taybi syndrome with agenesis of corpus callosum19 março 2025
-
Approach to inherited hypertrichosis: A brief review - Indian19 março 2025
você pode gostar
-
Pokemon Badges Evees Family Vaporeon Jolteon Espeon Umbreon Pins Brooches Eeveelution Box Collection Pocket Monster Toys Kids - AliExpress19 março 2025
-
Câmbio Logitech Driving Force Shifter para G29, G920 e G92319 março 2025
-
i bought liberty city stories but someone sent me china town wars19 março 2025
-
Hideo Kojima Can't Stop Binging Time Loop Anime Summer Time Rendering19 março 2025
-
Download Basketball Arena: Online Game on PC (Emulator) - LDPlayer19 março 2025
-
PDF) A capacidade essencial dos jogos na educação: estudo do Minecraft19 março 2025
-
I love HP memes! 😂😁19 março 2025
-
Valvrave the Liberator19 março 2025
-
Pterosauria19 março 2025
-
My life in new york PT-BR - O melhor simulador de vida para Android/Java - Como jogar19 março 2025