Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri, Parasites & Vectors
Por um escritor misterioso
Last updated 21 abril 2025

Background Heligmosomoides bakeri (often mistaken for Heligmosomoides polygyrus) is a promising model for parasitic nematodes with the key advantage of being amenable to study and manipulation within a controlled laboratory environment. While draft genome sequences are available for this worm, which allow for comparative genomic analyses between nematodes, there is a notable lack of information on its gene expression. Methods We generated biologically replicated RNA-seq datasets from samples taken throughout the parasitic life of H. bakeri. RNA from tissue-dwelling and lumen-dwelling worms, collected under a dissection microscope, was sequenced on an Illumina platform. Results We find extensive transcriptional sexual dimorphism throughout the fourth larval and adult stages of this parasite and identify alternative splicing, glycosylation, and ubiquitination as particularly important processes for establishing and/or maintaining sex-specific gene expression in this species. We find sex-linked differences in transcription related to aging and oxidative and osmotic stress responses. We observe a starvation-like signature among transcripts whose expression is consistently upregulated in males, which may reflect a higher energy expenditure by male worms. We detect evidence of increased importance for anaerobic respiration among the adult worms, which coincides with the parasite’s migration into the physiologically hypoxic environment of the intestinal lumen. Furthermore, we hypothesize that oxygen concentration may be an important driver of the worms encysting in the intestinal mucosa as larvae, which not only fully exposes the worms to their host’s immune system but also shapes many of the interactions between the host and parasite. We find stage- and sex-specific variation in the expression of immunomodulatory genes and in anthelmintic targets. Conclusions We examine how different the male and female worms are at the molecular level and describe major developmental events that occur in the worm, which extend our understanding of the interactions between this parasite and its host. In addition to generating new hypotheses for follow-up experiments into the worm’s behavior, physiology, and metabolism, our datasets enable future more in-depth comparisons between nematodes to better define the utility of H. bakeri as a model for parasitic nematodes in general. Graphical Abstract

Frontiers The Two Faces of Nematode Infection: Virulence and

The genome and lifestage-specific transcriptomes of a plant

Exosomes secreted by nematode parasites transfer small RNAs to

Genome and transcriptome of the porcine whipworm Trichuris suis

The production of excretory-secretory molecules from

Understanding within-host processes (Part I) - Wildlife Disease

PDF) Trickle infection with Heligmosomoides polygyrus results in

Whipworm and roundworm infections

The genome and transcriptome of Haemonchus contortus, a key model

Transcriptional patterns of sexual dimorphism and in host

Dictyocaulus viviparus genome, variome and transcriptome elucidate
Recomendado para você
-
Life Cycle21 abril 2025
-
Winter white dwarf hamster - Wikipedia21 abril 2025
-
Life cycle of S. mansoni , illustrating the collection points for in21 abril 2025
-
Adult Neurogenesis Is Altered by Circadian Phase Shifts and the Duper Mutation in Female Syrian Hamsters21 abril 2025
-
The Life Cycle of Rodents - All Natural Pest Elimination21 abril 2025
-
Life Cycle of a Guinea Pig (Heinemann by Royston, Angela21 abril 2025
-
Editing one gene extends mouse life expectancy by 23%21 abril 2025
-
ceo of hamster evolution — The Early Temperocene: 140 million years21 abril 2025
-
HAMSTERS!!!!!21 abril 2025
-
Syrian Hamster Lifespan: How Long Do Syrian Hamsters Live? - A-Z21 abril 2025
você pode gostar
-
Google Doodle desenvolve jogo de quebra-cabeça interativo de pizza21 abril 2025
-
kids-homeschool-activities-free-printables-finger-puppets – Wee21 abril 2025
-
how to download dream league soccer 202|TikTok Search21 abril 2025
-
Guide to Roblox – Forbes Advisor Australia21 abril 2025
-
Create a Flee The Facility Map Tier List - TierMaker21 abril 2025
-
Poço artesiano da Associação Mata Cavalo de Baixo, que disponibiliza21 abril 2025
-
Brasileirão: como foram os últimos jogos entre Cuiabá e Athletico?21 abril 2025
-
Sudden Attack - DominiosGames21 abril 2025
-
Bandai Relógio Japonês Genuíno De Anime Yokai, Relógio Dx Periférico Io-kai, Medalhas De Brinquedo, Armazenamento De Chave - Figuras De Ação - AliExpress21 abril 2025
-
Star Platinum PNG & Download Transparent Star Platinum PNG Images for Free - NicePNG21 abril 2025