Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri, Parasites & Vectors
Por um escritor misterioso
Last updated 01 abril 2025

Background Heligmosomoides bakeri (often mistaken for Heligmosomoides polygyrus) is a promising model for parasitic nematodes with the key advantage of being amenable to study and manipulation within a controlled laboratory environment. While draft genome sequences are available for this worm, which allow for comparative genomic analyses between nematodes, there is a notable lack of information on its gene expression. Methods We generated biologically replicated RNA-seq datasets from samples taken throughout the parasitic life of H. bakeri. RNA from tissue-dwelling and lumen-dwelling worms, collected under a dissection microscope, was sequenced on an Illumina platform. Results We find extensive transcriptional sexual dimorphism throughout the fourth larval and adult stages of this parasite and identify alternative splicing, glycosylation, and ubiquitination as particularly important processes for establishing and/or maintaining sex-specific gene expression in this species. We find sex-linked differences in transcription related to aging and oxidative and osmotic stress responses. We observe a starvation-like signature among transcripts whose expression is consistently upregulated in males, which may reflect a higher energy expenditure by male worms. We detect evidence of increased importance for anaerobic respiration among the adult worms, which coincides with the parasite’s migration into the physiologically hypoxic environment of the intestinal lumen. Furthermore, we hypothesize that oxygen concentration may be an important driver of the worms encysting in the intestinal mucosa as larvae, which not only fully exposes the worms to their host’s immune system but also shapes many of the interactions between the host and parasite. We find stage- and sex-specific variation in the expression of immunomodulatory genes and in anthelmintic targets. Conclusions We examine how different the male and female worms are at the molecular level and describe major developmental events that occur in the worm, which extend our understanding of the interactions between this parasite and its host. In addition to generating new hypotheses for follow-up experiments into the worm’s behavior, physiology, and metabolism, our datasets enable future more in-depth comparisons between nematodes to better define the utility of H. bakeri as a model for parasitic nematodes in general. Graphical Abstract

Frontiers The Two Faces of Nematode Infection: Virulence and

The genome and lifestage-specific transcriptomes of a plant

Exosomes secreted by nematode parasites transfer small RNAs to

Genome and transcriptome of the porcine whipworm Trichuris suis

The production of excretory-secretory molecules from

Understanding within-host processes (Part I) - Wildlife Disease

PDF) Trickle infection with Heligmosomoides polygyrus results in

Whipworm and roundworm infections

The genome and transcriptome of Haemonchus contortus, a key model

Transcriptional patterns of sexual dimorphism and in host

Dictyocaulus viviparus genome, variome and transcriptome elucidate
Recomendado para você
-
Dwarf Hamster Lifespan: How Long Do Dwarf Hamsters Live? - A-Z Animals01 abril 2025
-
Hamster - Animal Facts for Kids - Characteristics & Pictures01 abril 2025
-
Life Cycle of a Hamster by Amanda Inman on Prezi Next01 abril 2025
-
Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster01 abril 2025
-
Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters - ScienceDirect01 abril 2025
-
Hamster Facts: Lesson for Kids01 abril 2025
-
Life Cycle of a Guinea Pig (Heinemann by Royston, Angela01 abril 2025
-
Hamster (Golden)01 abril 2025
-
Can I separate baby Syrian hamsters from their mother when their eyes are opened? - Quora01 abril 2025
-
Dawf Hamster Wooden House Detachable Roof Climbing Ladder for Sugar Glider01 abril 2025
você pode gostar
-
Новости Eye drawing, Drawing tips, Anime drawings tutorials01 abril 2025
-
Buy Xbox 360 Xb360 Mortal Kombat Komplete01 abril 2025
-
40+ Roblox Music Codes IDs (MARCH 2023) *WORKING*01 abril 2025
-
Magical Girl Site Vol.1 - Manga Overview01 abril 2025
-
Noclip01 abril 2025
-
Wu-Tang Clan x Albino & Preto Medicom Toy BE@BRICK 100%/400%01 abril 2025
-
Dragon Ball Super Hero, Takagi-san Movie Take 1st and 6th Place at01 abril 2025
-
Gollum Mask - The Hobbit - Hollywood Toys & Costumes01 abril 2025
-
Lords Mobile Codes and how to redeem them01 abril 2025
-
What new emojis are available on Apple's iOS 15.4?01 abril 2025