Effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in nasal surgery: a randomized controlled trial, Patient Safety in Surgery
Por um escritor misterioso
Last updated 07 junho 2024
Maintenance of adequate peripheral perfusion during controlled hypotension is necessary for patient safety and improved surgical outcomes during controlled hypotension in nasal surgery. The hypothesis of this study was to investigate the effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in patients undergoing nasal surgery. A total of 50 patients were randomly assigned into two equal groups in this double-blind clinical study: the magnesium sulfate group; received 40 mg/kg loading dose of intravenous (IV) magnesium sulfate followed by 10–15 mg/kg/h continuous IV infusion and the labetalol group; received 0.25 mg/kg loading dose of IV labetalol followed by 0.5–1 mg/kg/h continuous IV infusion to achieve a mean arterial blood pressure (MABP) of = 55–65 mmHg. The primary outcome was to compare the effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion during nasal surgery. The secondary outcomes were the assessment of serum lactate, postoperative pain, time to the first call for pethidine (rescue analgesic) and total pethidine consumption. PPI was comparable between the groups at baseline, intubation, and 5 min. In contrast, magnesium sulfate group had a significantly higher PPI than the labetalol group. The magnesium sulfate group had a significantly higher MABP and heart rate compared to labetalol group. The time to reach the target MABP was significantly prolonged in magnesium sulfate than the labetalol group [21.6 ± 1.7 vs 6.9 ± 1.5] min. VAS scores were significantly lower for 2 hs postoperatively in the magnesium sulfate group than the labetalol group. The time to first call of pethidine was significantly prolonged in the magnesium sulfate group compared to the labetalol group [113.1 ± 5.2 vs 28.2 ± 1.5] min. Magnesium sulfate maintains wider PPI and offers better postoperative pain relief compared to labetalol during induced hypotension in nasal surgery. Institutional review board approval (ref: 6601/20–12-2020). Clinicaltrial.gov (ref: NCT04688203 , date of registration: 29 -12–2020).
Analgesia and Anesthesia for the Obstetric Patient by
Obstetric Regional Anesthesia - NYSORA
Anaesthesia for laparoscopic surgeries
Anaesthesia for laparoscopic surgeries
IJERPH, Free Full-Text
PDF) Comparison of different methods of general anaesthesia for
Signs and symptoms (Section II) - Post-Anesthesia Care
Effects of esmolol continuous infusion on blood loss in patients
Frontiers The effects of perioperative dexmedetomidine infusion
Physiological Changes in the Pregnancy and Anesthetic Implication
Effects of esmolol continuous infusion on blood loss in patients
Analgesia and Anesthesia for the Obstetric Patient by
Management of Patients after Vascular Surgery - ppt download
Recomendado para você
-
Labetalol: Uses, Side Effects, Dosage & Reviews07 junho 2024
-
The Safety of High Dose Labetalol in the Pregnant Population07 junho 2024
-
Labetalol Tablet IP07 junho 2024
-
Labetalol HCL Market: Comprehensive Assessment by Type, Application, and Geography, by Nolalockman, Dec, 202307 junho 2024
-
Absorption spectra of: (A) acebutolol (1), atenolol (2), labetalol (3)07 junho 2024
-
MEDBI – You Demand We Serve07 junho 2024
-
Comparing Labetalol and Nitroglycerine on Inducing Controlled Hypotension and Intraoperative Blood Loss in Rhinoplasty: A Single-Blinded Clinical Trial, Anesthesiology and Pain Medicine07 junho 2024
-
Adam Horne - Actor - Carolina Talent07 junho 2024
-
Labetalol Hydrochloride, ラベタロール07 junho 2024
-
Metildopa 250mg EMS 30 Comprimidos Revestidos07 junho 2024
você pode gostar
-
Oh Holy Night - Christmas SVG Stock Vector07 junho 2024
-
pou 2 - Meme by BolsonaroRedditor222 :) Memedroid07 junho 2024
-
AmiAmi [Character & Hobby Shop] Toy'sworks Collection Niitengomu! - Hataraku Maou-sama! BOX(Released)07 junho 2024
-
Saiba mais dos jogos novatos que estão fazendo sucesso - Escola de07 junho 2024
-
T-Cross Sense PcD e notícias da semana : CARROS COM CAMANZI07 junho 2024
-
Paul Morphy: Partidas Completas (Complete Games) by Caparros07 junho 2024
-
Himena Brasil 🐶 R U NEXT? (@HimenaBrasil) / X07 junho 2024
-
Days with My Stepsister - Wikipedia07 junho 2024
-
Grim foxy consertado07 junho 2024
-
Comunidade Steam :: Sonic Mania07 junho 2024