A somatization comorbidity phenotype impacts response to therapy
Por um escritor misterioso
Last updated 21 junho 2024
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Background Comorbidities may contribute to disease activity and treatment response in rheumatoid arthritis (RA) patients. We defined a somatization comorbidity phenotype (SCP) and examined its influence on response to certolizumab pegol (CZP) using data from the PREDICT trial. Methods Patients in PREDICT were randomized to the patient-reported Routine Assessment of Patient Index Data 3 (RAPID3) or physician-based Clinical Disease Activity Index (CDAI) for treatment response assessment. Post-hoc analyses identified patients with the SCP, which included diagnosis of depression, fibromyalgia/myalgias, and/or use of medications indicated for treatment of depression, anxiety, or neuropathic pain. The effect of the SCP on RAPID3 or CDAI response at week 12 and low disease activity (LDA; Disease Activity Score in 28 joints based on erythrocyte sedimentation rate ≤ 3.2) at week 52, in week-12 responders, was analyzed using non-parametric analysis of covariance (ANCOVA). Results At baseline, 43% (313/733) of patients met the SCP classification. Patients with the SCP were 9% more likely to withdraw from the trial. American College of Rheumatology 20% (ACR20), ACR50, and ACR70 responses were 5–14% lower among those with the SCP, and 11% more patients reported adverse events (AEs). Patients without SCP in the CDAI arm were twice as likely to achieve LDA at week 52 compared with those with SCP (32% versus 16%). No differentiation by SCP was observed in the RAPID3 arm (pooled result 21.5%). Conclusions We operationalized a potentially important somatization comorbidity phenotype in a trial setting that was associated with a substantially lower likelihood of treatment response and a higher frequency of AEs. Including large numbers of patients with this phenotype in RA trials may reduce the measured clinical effectiveness of a new molecule. Trial registration ClinicalTrials.gov, NCT01255761 . Registered on 6 December 2010.
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Mechanisms predicting response to antidepressants.
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IJMS, Free Full-Text
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Preliminary proposal for a revision to the Diagnostic and Statistical
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Impact of predictive, preventive and precision medicine strategies in epilepsy
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Frontiers Insomnia – A Heterogenic Disorder Often Comorbid With Psychological and Somatic Disorders and Diseases: A Narrative Review With Focus on Diagnostic and Treatment Challenges
![A somatization comorbidity phenotype impacts response to therapy](https://www.thelancet.com/cms/asset/be846cc3-0395-4c9f-8880-e317a0412739/gr1.jpg)
Towards better care for women with schizophrenia-spectrum disorders - The Lancet Psychiatry
![A somatization comorbidity phenotype impacts response to therapy](https://www.mdpi.com/cancers/cancers-15-04357/article_deploy/html/images/cancers-15-04357-g001.png)
Cancers, Free Full-Text
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Frontiers Editorial: Brain and Somatization Symptoms in Psychiatric Disorders
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Genes, Free Full-Text
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Frontiers A Longitudinal Study on Attenuated Structural Covariance in Patients With Somatic Symptom Disorder
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Improving outcome after paediatric concussion: challenges and possibilities - The Lancet Child & Adolescent Health
![A somatization comorbidity phenotype impacts response to therapy](https://www.researchgate.net/publication/353393189/figure/fig1/AS:1048520622608384@1626998205731/Phenotypic-associations-between-OCD-and-other-psychiatric-disorders-grouped-by-their.png)
Phenotypic associations between OCD and other psychiatric disorders
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