Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Developmental regulation of early dendritic protrusion density and

Brain Sciences, Free Full-Text

IJMS, Free Full-Text

Frontiers Local Translation Across Neural Development: A Focus

Pten heterozygosity restores neuronal morphology in fragile X

A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum

Biology, Free Full-Text

Altered mRNA transport, docking, and protein translation in

Altered mRNA transport, docking, and protein translation in

Multifarious Functions of the Fragile X Mental Retardation Protein

Presynaptic FMRP and local protein synthesis support structural

Mechanism-Based Treatments in Neurodevelopmental Disorders