Viruses, Free Full-Text
Por um escritor misterioso
Last updated 19 março 2025

Human cytomegalovirus (HCMV) tegument protein pp150 is essential for the completion of the final steps in virion maturation. Earlier studies indicated that three pp150nt (N-terminal one-third of pp150) conformers cluster on each triplex (Tri1, Tri2A and Tri2B), and extend towards small capsid proteins atop nearby major capsid proteins, forming a net-like layer of tegument densities that enmesh and stabilize HCMV capsids. Based on this atomic detail, we designed several peptides targeting pp150nt. Our data show significant reduction in virus growth upon treatment with one of these peptides (pep-CR2) with an IC50 of 1.33 μM and no significant impact on cell viability. Based on 3D modeling, pep-CR2 specifically interferes with the pp150–capsid binding interface. Cells pre-treated with pep-CR2 and infected with HCMV sequester pp150 in the nucleus, indicating a mechanistic disruption of pp150 loading onto capsids and subsequent nuclear egress. Furthermore, pep-CR2 effectively inhibits mouse cytomegalovirus (MCMV) infection in cell culture, paving the way for future animal testing. Combined, these results indicate that CR2 of pp150 is amenable to targeting by a peptide inhibitor, and can be developed into an effective antiviral.

A Brief History of Computer Viruses & What the Future Holds

Virus infection style font Royalty Free Vector Image
Coxsackie B viruses and myalgic encephalomyelitis. - Abstract - Europe PMC

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022

Fake virus warning pop-up: how to remove it

Frontiers Pandemics Throughout History

Abstract Display Option Added For PubMed Labs Search Results. NLM Technical Bulletin. 2018 Sep–Oct

The Top 10 Worst Computer Viruses in History
Reactivity of Enveloped Virus Genome, Proteins, and Lipids with Free Chlorine and UV254

Journal of Viral Hepatitis
virusfree

Free Entry Virus - Colaboratory
An RNA-dependent DNA polymerase, different from the known viral reverse transcriptases, in the chicken system. - Abstract - Europe PMC
Recomendado para você
-
SWITCHBLADE Skull-T – Nomad Cigars19 março 2025
-
SCP: Lockdown - UGC - Halo Infinite19 março 2025
-
ADDENDUM 12] Target has been successfully contained in site-44, Testi19 março 2025
-
1pcs new IFM IIS244 One year warranty19 março 2025
-
1PC IFM Proximity Switch IGS292 New19 março 2025
-
Sophia Manifests Yaldabaoth Framed Art Print for Sale by echomultiverse19 março 2025
-
First post: Scp 3940 (idk lol)19 março 2025
-
MLB Anubisa, Kwami, hero and a weapon19 março 2025
-
J. Imaging, Free Full-Text19 março 2025
-
Intentional Automata: A Context-Dependent Model for Component Connectors19 março 2025
você pode gostar
-
Home Page19 março 2025
-
Little Alchemy 2 (by Recloak) - free offline puzzle game for19 março 2025
-
Bologna :: Itália :: Perfil da Equipa19 março 2025
-
Round 6] French Fries Game Sound 123/Sound Effect - Squid Game Sound effects19 março 2025
-
Gyaru That Becomes Menhera After 10 Days Manga Online Free - Manganato19 março 2025
-
Barefoot: Film Review – The Hollywood Reporter19 março 2025
-
Recarga Free Fire: 110% de bônus é liberado em fevereiro 202219 março 2025
-
Desapego Games - Roblox > Conta de Murder Mystery 2 e Brookhaven19 março 2025
-
30 Ninja Tattoos für Männer – alte japanische Krieger Design-Ideen - Mann Stil, Tattoo19 março 2025
-
Rayman Legends (Nintendo Wii U, 2013) - Japanese Version for sale online19 março 2025