Viruses, Free Full-Text
Por um escritor misterioso
Last updated 19 março 2025

The successful development of a chemoprophylaxis against SARS-CoV-2 could provide a tool for infection prevention that is implementable alongside vaccination programmes. Nafamostat is a serine protease inhibitor that inhibits SARS-CoV-2 entry in vitro, but it has not been characterised for chemoprophylaxis in animal models. Clinically, nafamostat is limited to intravenous delivery and has an extremely short plasma half-life. This study sought to determine whether intranasal dosing of nafamostat at 5 mg/kg twice daily was able to prevent the airborne transmission of SARS-CoV-2 from infected to uninfected Syrian Golden hamsters. SARS-CoV-2 RNA was detectable in the throat swabs of the water-treated control group 4 days after cohabitation with a SARS-CoV-2 inoculated hamster. However, throat swabs from the intranasal nafamostat-treated hamsters remained SARS-CoV-2 RNA negative for the full 4 days of cohabitation. Significantly lower SARS-CoV-2 RNA concentrations were seen in the nasal turbinates of the nafamostat-treated group compared to the control (p = 0.001). A plaque assay quantified a significantly lower concentration of infectious SARS-CoV-2 in the lungs of the nafamostat-treated group compared to the control (p = 0.035). When taken collectively with the pathological changes observed in the lungs and nasal mucosa, these data are strongly supportive of the utility of intranasally delivered nafamostat for the prevention of SARS-CoV-2 infection.

Coronavirus

A Brief History of Computer Viruses & What the Future Holds

Free Online Virus Scan

AVG Antivirus Protection & Internet Security Pricing in 2023

Cartoon Viruses and Bacteria Vector Clipart Set. Microscopic - Norway

Winter collection - Flu virus

Cartoon viruses. Germs virus character, funny bacteria types

5 Best Free Online Virus Scanners & Removers for 2023

Avira Free Antivirus for Windows free download
Recomendado para você
-
The Hamster's Lifespan - 7 Things Affecting It19 março 2025
-
Winter white dwarf hamster - Wikipedia19 março 2025
-
Hamster - Animal Facts for Kids - Characteristics & Pictures19 março 2025
-
Life Cycle of Hamsters19 março 2025
-
New animal model to aid in the development of Covid-19 cure – The Childrens Post of India19 março 2025
-
Life Cycle19 março 2025
-
Pika Life Cycle Clipart Set Download - Clipart 4 School19 março 2025
-
Prolee Hamster Cage Wooden 32 Inch Mice and Rat Habitat Openable Top with Acrylic Sheets Solid Built : Pet Supplies19 março 2025
-
Pathogens, Free Full-Text19 março 2025
-
Should I Get Hamster or Guinea Pig?19 março 2025
você pode gostar
-
About: Minas Tirith Map For Minecraft (Google Play version)19 março 2025
-
Wooly from amanda the adventurer by RaidenKramata on Newgrounds19 março 2025
-
CAT GAME: PLAYER 001, Family, Home, Office, Working, Skill Development with Game and Application Program, Simple19 março 2025
-
Começam os Jogos Estudantis de Caratinga19 março 2025
-
Gostaria de assistir aos jogos de basquete do Minas Tênis Clube de19 março 2025
-
FEATURE: Head Space - Drifters and The Theater of Violence19 março 2025
-
30 People Who Became Highly Successful Later in Life19 março 2025
-
Dragon Ball Super: Broly- Manga Style by Anorkius-TheNERX on DeviantArt19 março 2025
-
Popular Google Doodle Games/How to Play Google Doodle Games Cricket/Fischinger / Coding Play at Home19 março 2025
-
Shirts for Roblox by MOBILE ALCHEMY LTD19 março 2025