The effect of incorporating an arterial pH target during apnea test for brain death determination, Journal of Intensive Care
Por um escritor misterioso
Last updated 22 abril 2025

Background Persistent apnea despite an adequate rise in arterial pressure of CO2 is an essential component of the criteria for brain death (BD) determination. Current guidelines vary regarding the utility of arterial pH changes during the apnea test (AT). We aimed to study the effect of incorporating an arterial pH target < 7.30 during the AT (in addition to the existing PaCO2 threshold) on brain death declarations. Methods We performed retrospective analysis of consecutive adult patients who were diagnosed with BD and underwent AT at the Cleveland Clinic over the last 10 years. Data regarding baseline and post-AT blood gas analyses were collected and analyzed. Results Ninety-eight patients underwent AT in the study period, which was positive in 89 (91%) and inconclusive in 9 (9%) patients. The mean age was 50 years old (standard deviation [SD] 16) and 54 (55%) were female. The most common etiology BD was hypoxic ischemic brain injury (HIBI) due to cardiac arrest (42%). Compared to those with positive AT, patients with inconclusive AT had a higher post-AT pH (7.24 vs 7.17, p = 0.01), lower PaO2 (47 vs 145, p < 0.01), and a lower PaCO2 (55 vs 73, p = 0.01). Among patients with a positive AT using PaCO2 threshold alone, the frequency of patients with post-AT pH < 7.30 was 95% (83/87). Conclusion Implementing a BD criteria requiring both arterial pH and PaCO2 thresholds reduced the total number of positive ATs; these inconclusive cases would have required longer duration of AT to reach both targets, repeated ATs, or ancillary studies to confirm BD. The impact of this on the overall number BD declarations requires further research.

2022 ACC/AHA/HFSA Guideline for the Management of Heart Failure

European Respiratory Society statement on sleep apnoea, sleepiness

Sudden Cardiac Death in People With Schizophrenia: Higher Risk

Prevention of Hypoxemia During Apnea Testing: A Comparison of

Personalized Blood Pressure Management During Cardiac Surgery With
Wearable Sensing Devices for Point of Care Diagnostics

EX-99.2

Carbogen for Apnea Testing During the Brain Death Declaration

Cancer (Molecular) 12 - Oregon Health & Science University
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