α-Synuclein Aggregation in Treatment of Parkinson's Disease
Por um escritor misterioso
Last updated 04 julho 2024
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://encyclopedia.pub/media/item_content/202303/642633a6f1209pharmaceutics-15-00839-g001.png)
Parkinson’s disease, the second most common neurodegenerative disorder worldwide, is characterized by the accumulation of protein deposits in the dopaminergic neurons. These deposits are primarily composed of aggregated forms of α-Synuclein (α-Syn). PD is a complex pathology initially associated with motor deficiencies, as a result of an acute neuronal loss in substantia nigra pars compacta (SNc), with a significant dopaminergic (DA) impairment.
Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein in the Presence of Dopamine
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41419-023-05672-9/MediaObjects/41419_2023_5672_Fig1_HTML.png)
Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://iiif.elifesciences.org/lax/56825%2Felife-56825-fig3-v2.tif/full/,1500/0/default.jpg)
α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://pharmrev.aspetjournals.org/content/pharmrev/74/1/207/F2.large.jpg)
Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://www.pnas.org/cms/asset/82935ed3-5bab-4328-8879-161e8e666f42/keyimage.jpg)
Chemical disaggregation of alpha-synuclein fibrils as a therapy for synucleinopathies
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://www.degruyter.com/document/doi/10.1515/nf-2018-0029/asset/graphic/j_nf-2018-0029_fig_001.jpg)
Alpha-synuclein as therapeutic target in Parkinson's disease
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://www.life-science-alliance.org/content/lsa/5/11/e202201366/F2.large.jpg)
Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson's in vivo models
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2Fs13024-020-00368-6/MediaObjects/13024_2020_368_Fig1_HTML.png)
Initiation and propagation of α-synuclein aggregation in the nervous system, Molecular Neurodegeneration
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41419-022-05030-1/MediaObjects/41419_2022_5030_Fig1_HTML.png)
p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnrd.2017.95/MediaObjects/41573_2017_Article_BFnrd201795_Fig1_HTML.jpg)
Zeroing in on neurodegenerative α-synuclein
![α-Synuclein Aggregation in Treatment of Parkinson's Disease](https://onlinelibrary.wiley.com/cms/asset/a27e64f9-b6d0-4283-85d5-c8092a98ca1b/brb32628-fig-0001-m.jpg)
Modeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing mice - Aniszewska - 2022 - Brain and Behavior - Wiley Online Library
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