Pathophysiology, Free Full-Text
Por um escritor misterioso
Last updated 20 março 2025

Diabetes Mellitus (DM) is a complex metabolic disorder associated with multiple microvascular complications leading to nephropathy, retinopathy, and neuropathy. Mounting evidence suggests that red blood cell (RBC) alterations are both a cause and consequence of disturbances related to DM-associated complications. Importantly, a significant proportion of DM patients develop varying degrees of anemia of confounding etiology, leading to increased morbidity. In chronic hyperglycemia, RBCs display morphological, enzymatic, and biophysical changes, which in turn prime them for swift phagocytic clearance from circulation. A multitude of endogenous factors, such as oxidative and dicarbonyl stress, uremic toxins, extracellular hypertonicity, sorbitol accumulation, and deranged nitric oxide metabolism, have been implicated in pathological RBC changes in DM. This review collates clinical laboratory findings of changes in hematology indices in DM patients and discusses recent reports on the putative mechanisms underpinning shortened RBC survival and disturbed cell membrane architecture within the diabetic milieu. Specifically, RBC cell death signaling, RBC metabolism, procoagulant RBC phenotype, RBC-triggered endothelial cell dysfunction, and changes in RBC deformability and aggregation in the context of DM are discussed. Understanding the mechanisms of RBC alterations in DM provides valuable insights into the clinical significance of the crosstalk between RBCs and microangiopathy in DM.

Fundamentals of Pathology

General and systematic pathology

Turkish J Pathology on X: Have you read the paper on histopathological findings in #cysticercosis by Lobo et. al in the latest issue of @TurkJPath ? 🤓 Free full text ➡️ #

Test Bank For Pathophysiology 7th Edition by Jacquelyn L. Banasik, All Chapters Covered, A+ guide. - Pathophysiology 7th Edition by Jacquelyn L Banasi - Stuvia NL

Interpretable deep learning model to predict the molecular classification of endometrial cancer from haematoxylin and eosin-stained whole-slide images: a combined analysis of the PORTEC randomised trials and clinical cohorts - The Lancet
The American Journal of Pathology

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

Free Download - Pathophysiology Made Easy eBook (PDF) - Rish Academy

Pathophysiology Stock Footage ~ Royalty Free Stock Videos

SARS-CoV-2 pathogenesis Nature Reviews Microbiology

Breast Cancer Treatment in Integrated Care Process in Andalusia: The Challenge of Multidisciplinarity, IJERPH, Free Full-Text

JACC: Clinical Electrophysiology: Vol 5, No 2
Recomendado para você
-
MH Official Matka – Apps on Google Play20 março 2025
-
MATKA GAME OFFICIAL APP APK (Android App) - Free Download20 março 2025
-
Buy MRP Multipurpose Matka Stand Pot Stand (Red) Online at Low20 março 2025
-
LG G4, Official Marshmallow update in Korea. : r/Android20 março 2025
-
gm goldan matka Download Apps & Games APK for android20 março 2025
-
RS GAMES - Online play Matka app official APK Download for Windows20 março 2025
-
Buy Online Bandhani Matki Diya - 4 Pack (#91222) (4 diyas20 março 2025
-
Cancers, Free Full-Text20 março 2025
-
GOLDEN MATKA - Online Play Matka App APK (Android App20 março 2025
-
Ghrelin's Matka Design diyaset of 12, GM-29a, Matka, Jute : : Home & Kitchen20 março 2025
você pode gostar
-
FNAF/C4d] The Puppet Render by 19SharkyTheShark19 on DeviantArt20 março 2025
-
TENSEI KIZOKU 2 TEMPORADA QUANDO CHEGA NA CRUNCHYROLL?20 março 2025
-
50 Questions to Increase Intimacy20 março 2025
-
DISC] Isekai Shoukan wa Nidome Desu - Ch. 44 : r/manga20 março 2025
-
Jogo de animais com impressão digital passo a passo, pintura de bebês com os dedos aprendendo atividades de berçário de desenho na escola ou modelo de vetor de jardim de infância ilustração20 março 2025
-
Magnus Carlsen: A Look into the Chess Maestro's Life and Triumphs - SarkariResult20 março 2025
-
Laura Bailey - IMDb20 março 2025
-
Sonic Frontiers The Final Horizon Update Coming This Year - IGN20 março 2025
-
Xeque Mate - Retrô Bar - Véspera de feriado é sim tipo sexta!!! . . . #2sextas #vésperadeferiado #karaokrêo #tudojunto #mesmodia #loucura #sópravcs #sónoxeque #quartasualinda20 março 2025
-
Oniai Jojo Pose Lair of the Idle20 março 2025