PDF] Immunoregulatory cytokines and chronic tonsillitis

The distribution of cells producing cytokines: tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in different morphological sections of tonsils in patients with tonsillar hypertrophy and recurrent tonsillitis was determined. The purposes of the present study were to determine the distribution of cells producing cytokines: tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in different morphological sections of tonsils in patients with tonsillar hypertrophy (TH) and recurrent tonsillitis (RT), to analyze the level of production of these cytokines in TH and RT and evaluate the potential of peripheral blood lymphocytes for production of interferon-γ (IFN-γ) and interleukin 4 (IL-4). Analyzed materials consisted of the tonsils after tonsillectomy and blood taken from patients right before tonsillectomy (study group) and blood taken from healthy donors (control group).We used histological and immunohistochemical method, morphometric methods for the quantification of TNF-α and IL- 6 producing cells and immunological methods for determining the concentration of IFN-γ and IL-4. Most of TNF-α producing cells are settled in the subepithelial region (55%). Numerical density of TNF-α producing cells in the crypt epithelium, subepithelial and interfollicular region was significantly higher in RT compared with TH. The concentration of IFN-γ is three times higher in RT then in TH. After the stimulation of peripheral blood lymphocytes in culture there was no significant increase in concentrations of IL- 4. The index of stimulation of IFN-γ was the highest in the RT, and of IL- 4 in TH. The production of Th1-type cytokines (TNF-α and IFN-γ) is higher in RT compared with TH. In both forms of tonsillitis, production of Th1-type cytokines is higher in relation to the production of Th2-type cytokines (IL-6 and IL-4).

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Characterization of Tonsil Microbiota and Their Effect on Adenovirus Reactivation in Tonsillectomy Samples

Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS‐associated immunopathologies - Soderholm - 2018 - Journal of Leukocyte Biology - Wiley Online Library

Immunobiology of the Tonsils and Adenoids - ScienceDirect

Tonsillar transcriptional profiles in atopic and non‐atopic subjects - Hanif - 2023 - Allergy - Wiley Online Library

PDF] VITAMIN D IMMUNOMODULATORY EFFECT

PDF) Immune response profile in Hesperidin treated mice suffering from experimental autoimmune encephalomyelitis

IJMS, Free Full-Text

PDF) Selenium, Zinc, Copper, and Total Antioxidant Status in the Serum of Patients with Chronic Tonsillitis

Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis - Mikola - 2018 - Clinical and Translational Allergy - Wiley Online Library