JoF, Free Full-Text
Por um escritor misterioso
Last updated 14 março 2025

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by Paracoccidioides brasiliensis, a thermally dimorphic fungus, which is the most frequent endemic systemic mycosis in many Latin American countries, where ~10 million people are believed to be infected. In Brazil, it is ranked as the tenth most common cause of death among chronic infectious diseases. Hence, vaccines are in development to combat this insidious pathogen. It is likely that effective vaccines will need to elicit strong T cell-mediated immune responses composed of IFNγ secreting CD4+ helper and CD8+ cytolytic T lymphocytes. To induce such responses, it would be valuable to harness the dendritic cell (DC) system of antigen-presenting cells. To assess the potential of targeting P10, which is a peptide derived from gp43 secreted by the fungus, directly to DCs, we cloned the P10 sequence in fusion with a monoclonal antibody to the DEC205 receptor, an endocytic receptor that is abundant on DCs in lymphoid tissues. We verified that a single injection of the αDEC/P10 antibody caused DCs to produce a large amount of IFNγ. Administration of the chimeric antibody to mice resulted in a significant increase in the levels of IFN-γ and IL-4 in lung tissue relative to control animals. In therapeutic assays, mice pretreated with αDEC/P10 had significantly lower fungal burdens compared to control infected mice, and the architecture of the pulmonary tissues of αDEC/P10 chimera-treated mice was largely normal. Altogether, the results obtained so far indicate that targeting P10 through a αDEC/P10 chimeric antibody in the presence of polyriboinosinic: polyribocytidylic acid is a promising strategy in vaccination and therapeutic protocols to combat PCM.
Farnood By Jaun Elia : Jaun Elia : Free Download, Borrow, and Streaming : Internet Archive
:max_bytes(150000):strip_icc()/176737834-56a7924d5f9b58b7d0ebc94e.jpg)
Full-Text Psychology Journals and Articles

eLibraries

Letterhead Fonts / LHF Jalopy Joe / Period Fonts

Cureus, The Efficacy of Telepsychiatry in Addiction Patients: A Systematic Review

Journal of Internal Medicine - Wiley Online Library

PDF) Status of open access in the biomedical field in 2005 M Matsubayashi, K Kurata, Y Sakai, T Morioka, S Kato, S Mine, S Ueda Journal of the Medical Library Association: JMLA

Jo Font : Download For Free, View Sample Text, Rating And More On

PubMed (AUSP) 2008

IJMS, Free Full-Text

Viruses, Free Full-Text
Guided paragraph writing : a first course in English composition with structural practice : Jupp, T. C. (Thomas Cyprian) : Free Download, Borrow, and Streaming : Internet Archive

The role of bone-specific biomarkers in chronic periodontitis diagnosis and treatment outcomes - a systematic review
Recomendado para você
-
Empresa de telemarketing oferece mais de 500 vagas de emprego home office e presenciais para pessoas com ensino médio completo - CPG Click Petroleo e Gas14 março 2025
-
Marcia Persi14 março 2025
-
IJMS, Free Full-Text14 março 2025
-
ClickAR - Apps on Google Play14 março 2025
-
Antioxidant and Cytotoxic Activity of Essential Oils and Their Principal Components: Spectrophotometric, Voltammetric, and Theoretical Investigation of the Chelating Effect of Eugenol and Carvacrol14 março 2025
-
Global go to Think Tank 2015 (Universidad de Pensilvania) by Navarra Capital - Issuu14 março 2025
-
Frontiers Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor14 março 2025
-
INTEROPERABILIDADE ENTRE ARCHICAD E REVIT POR MEIO DO FORMATO IFC14 março 2025
-
Revit Public Roadmap Update14 março 2025
-
Webinar: Future Sensor Shield e Renesas Synergy, Perfeita Sinergia para IOT14 março 2025
você pode gostar
-
Mystery Solved: Here's Who Plays the Reimagined Scooby Gang in14 março 2025
-
Atirei o Pau no Gato. Quem cantou melhor? #atireiopaunogato #atireiopa14 março 2025
-
I'm drawing meowbahh- O-o (I don't know what's on my mind)14 março 2025
-
home14 março 2025
-
Subway Surfers Do Naag Apk para Android [versão Mod 202314 março 2025
-
Go Shawty It's Sherbert Day, 8oz Scented Candle - (Choose Your Scent)14 março 2025
-
AGAINST definition in American English14 março 2025
-
JoJo's Bizarre Adventure: Diamond Is Unbreakable (Legendado)14 março 2025
-
Pikachu Evolution As Monsters.14 março 2025
-
Top Baby Boy Names That Start With B14 março 2025