IJMS, Free Full-Text
Por um escritor misterioso
Last updated 19 março 2025

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a highly aggressive malignancy, with poorer prognosis in infants than in adults. A genetic signature has been associated with this outcome but, remarkably, leukemogenesis is commonly triggered by genetic alterations of embryonic origin that involve the deregulation of chromatin remodelers. This review considers in depth how the alteration of epigenetic profiles (at DNA and histone levels) induces an aberrant phenotype in B lymphocyte progenitors by modulating the oncogenic drivers and tumor suppressors involved in key cancer hallmarks. DNA methylation patterns have been widely studied in BCP-ALL and their correlation with survival has been established. However, the effect of methylation on histone residues can be very different. For instance, methyltransferase KMT2A gene participates in chromosomal rearrangements with several partners, imposing an altered pattern of methylated H3K4 and H3K79 residues, enhancing oncogene promoter activation, and conferring a worse outcome on affected infants. In parallel, acetylation processes provide an additional layer of epigenetic regulation and can alter the chromatin conformation, enabling the binding of regulatory factors. Therefore, an integrated knowledge of all epigenetic disorders is essential to understand the molecular basis of BCP-ALL and to identify novel entry points that can be exploited to improve therapeutic options and disease prognosis.
Cleverativity on LinkedIn: IJMS, Free Full-Text

IJMS, Free Full-Text
Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text
Recomendado para você
-
Manual de Rede Sudeste by CARE PLUS - Issuu19 março 2025
-
Bronstein popular -_exames_a_preços_populares19 março 2025
-
Sharon Stone with her son Roan Joseph Bronstein on arrival GQ Men19 março 2025
-
Play Like Boris Spassky - Chess Lessons19 março 2025
-
The Top 10 Games Of The 1950s - Chess Lessons19 março 2025
-
AUTHOR - Andrew Meier - The Hampton Synagogue19 março 2025
-
Summer 2021 Brochure - The Hampton Synagogue19 março 2025
-
Como chegar até Bronstein Madureira (Laboratorio Bronstein19 março 2025
-
MD Anderson Annual Report 2014-2015 by MD Anderson Cancer Center19 março 2025
-
AI-powered interpretable imaging phenotypes noninvasively19 março 2025
você pode gostar
-
yu-ki. (@yuki_i_) / X19 março 2025
-
Real Madrid 5-3 Al Hilal: Los Blancos score five in eight-goal thriller to win Club World Cup - Eurosport19 março 2025
-
Def Jam Icon 2, The Def Jam Wrestling Wiki19 março 2025
-
Fremy Speeddraw Fanart by Panduffin on DeviantArt19 março 2025
-
ESO: How to Survive in Cyrodiil PVP at a Low Level - Lords of Gaming19 março 2025
-
Bocchi the Rock! Vol. 5 - Tokyo Otaku Mode (TOM)19 março 2025
-
Enisei é campeão russo, VRAC é campeão espanhol19 março 2025
-
Download Mini World: CREATA 0.57.10 APK for android free19 março 2025
-
Free STL file Spyra-Two Sling Mount 🎲・3D printable object to19 março 2025
-
Aesthetic Roblox Girl Wallpapers - Top Free Aesthetic Roblox Girl Backgrounds - WallpaperAccess19 março 2025