IJMS, Free Full-Text
Por um escritor misterioso
Last updated 31 outubro 2024
An apparent paradox exists between the evidence for spontaneous systemic T cell- mediated anti-tumor immune responses in cancer patients, observed particularly in their bone marrow, and local tumor growth in the periphery. This phenomenon, known as “concomitant immunity” suggests that the local tumor and its tumor microenvironment (TME) prevent systemic antitumor immunity to become effective. Oncolytic Newcastle disease virus (NDV), an agent with inherent anti-neoplastic and immune stimulatory properties, is capable of breaking therapy resistance and immunosuppression. This review updates latest information about immunosuppression by the TME and discusses mechanisms of how oncolytic viruses, in particular NDV, and cellular immunotherapy can counteract the immunosuppressive effect of the TME. With regard to cellular immunotherapy, the review presents pre-clinical studies of post-operative active-specific immunotherapy and of adoptive T cell-mediated therapy in immunocompetent mice. Memory T cell (MTC) transfer in tumor challenged T cell-deficient nu/nu mice demonstrates longevity and functionality of these cells. Graft-versus-leukemia (GvL) studies in mice demonstrate complete remission of late-stage disease including metastases and cachexia. T cell based immunotherapy studies with human cells in human tumor xenotransplanted NOD/SCID mice demonstrate superiority of bone marrow-derived as compared to blood-derived MTCs. Results from clinical studies presented include vaccination studies using two different types of NDV-modified cancer vaccine and a pilot adoptive T-cell mediated therapy study using re-activated bone marrow-derived cancer-reactive MTCs. As an example for what can be expected from clinical immunotherapy against tumors with an immunosuppressive TME, results from vaccination studies are presented from the aggressive brain tumor glioblastoma multiforme. The last decades of basic research in virology, oncology and immunology can be considered as a success story. Based on discoveries of these research areas, translational research and clinical studies have changed the way of treatment of cancer by introducing and including immunotherapy.
IJMS, Free Full-Text
Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS Free Full Text Recent Insights From Molecular Dynamics
IJMS, Free Full-Text
Ijms Free Full Text Hyaluronic Acid Influence On Normal And
Recomendado para você
-
Nintendo Switch - Wikipedia31 outubro 2024
-
Lista de jogos para Nintendo Switch – Wikipédia, a enciclopédia livre31 outubro 2024
-
Sega Genesis - Wikipedia31 outubro 2024
-
Legend Of Zelda Torrent31 outubro 2024
-
Super Bomberman R Review (Switch)31 outubro 2024
-
Zelda: Link's Awakening, Yuzu Early ASTC31 outubro 2024
-
The Legend of Zelda: Link's Awakening Switch Free Download31 outubro 2024
-
Download - ACNR31 outubro 2024
-
Baixar Zelda: Link's Awakening tradução - The Legend of Zelda31 outubro 2024
-
The Legend of Zelda: Ocarina of Time para PC agora suporta até31 outubro 2024
você pode gostar
-
Roblox SLENDER Profiles 2 😲31 outubro 2024
-
2023 VALORANT TOKYO MASTERS] ▻ 11th JUN 17:00 CST ▻ EDG vs T1 #edgwin # valorant #valorantmasters31 outubro 2024
-
Post Malone arrives like a rock star for two-night stand at Xcel Center31 outubro 2024
-
Voltou tudo ao normal kkkkkk - Melhor dos Animes31 outubro 2024
-
Jogo De Juntas Para Motosserra Stihl 382 Ms38231 outubro 2024
-
Monkey Tycoon Codes (December 2023) - Roblox31 outubro 2024
-
Rotten Sound (news, biography, albums, line-up, tour dates31 outubro 2024
-
Pin by Nicolle Silva on Imagens aleatórias31 outubro 2024
-
Jogos De Tabuleiro Mesa Xadrez De Metal Luxo Profissional Viagem Crianças Xadrez Figuras Medievais Histórico Jogo De Mesa Entretenimento - AliExpress31 outubro 2024
-
Pin de Ceffeelatte em Hinata hyuga Hinata hyuga, Kakashi desenho, Desenhos de anime31 outubro 2024