IJMS, Free Full-Text
Por um escritor misterioso
Last updated 19 março 2025

Cell death is an essential immunological apparatus of host defense, but dysregulation of mutually inclusive cell deaths poses severe threats during microbial and parasitic infections leading to deleterious consequences in the pathological progression of infectious diseases. Nucleotide-binding oligomerization domain (NOD)-Leucine-rich repeats (LRR)-containing receptors (NLRs), also called nucleotide-binding oligomerization (NOD)-like receptors (NLRs), are major cytosolic pattern recognition receptors (PRRs), their involvement in the orchestration of innate immunity and host defense against bacteria, viruses, fungi and parasites, often results in the cleavage of gasdermin and the release of IL-1β and IL-18, should be tightly regulated. NLRs are functionally diverse and tissue-specific PRRs expressed by both immune and non-immune cells. Beyond the inflammasome activation, NLRs are also involved in NF-κB and MAPK activation signaling, the regulation of type I IFN (IFN-I) production and the inflammatory cell death during microbial infections. Recent advancements of NLRs biology revealed its possible interplay with pyroptotic cell death and inflammatory mediators, such as caspase 1, caspase 11, IFN-I and GSDMD. This review provides the most updated information that caspase 8 skews the NLRP3 inflammasome activation in PANoptosis during pathogen infection. We also update multidimensional roles of NLRP12 in regulating innate immunity in a content-dependent manner: novel interference of NLRP12 on TLRs and NOD derived-signaling cascade, and the recently unveiled regulatory property of NLRP12 in production of type I IFN. Future prospects of exploring NLRs in controlling cell death during parasitic and microbial infection were highlighted.

IJMS Free Full-Text Research Advances In Mechanical, 52% OFF

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS Free Full-Text Research Advances In Mechanical, 52% OFF

IJMS Free Full-Text Research Advances In Mechanical, 52% OFF

IJMS, Free Full-Text
Recomendado para você
-
SpyraTwo19 março 2025
-
Spyra Three - Wasserpistole elektrisch19 março 2025
-
The Haunted Candy Hunt AR Game Lets You Become A Ghostbuster19 março 2025
-
Ecosystem Services from Forest Landscapes: Broadscale19 março 2025
-
Recent advances of targeting nicotinamide19 março 2025
-
SpyraOne Troubleshooting, Software Bug19 março 2025
-
Status of Reactive Non-Heme Metal–Oxygen Intermediates in Chemical19 março 2025
-
spyra電動水槍- 比價撿便宜- 優惠與推薦- 2023年11月19 março 2025
-
Frontiers The Significance of Neutrophil Extracellular Traps in19 março 2025
-
Mononuclear Manganese(III) Superoxo Complexes: Synthesis19 março 2025
você pode gostar
-
Jogos Xbox 360 transferência de Licença Mídia Digital - ASSASSINS CREED ROGUE DUBLADO19 março 2025
-
Personalização em Mochila ou Lancheira - 3130 - Personalize a19 março 2025
-
Fiquem ligados na cobertura da Chegada de Ultracriaturas: Los Angeles para um Desafio de minicoleção! – Pokémon GO19 março 2025
-
Rainbow Friends: Chapter 319 março 2025
-
Guest 666 by ArtC_EAWE on Sketchers United19 março 2025
-
Roblox Limited Item UAID 6810831274 - Rolimon's19 março 2025
-
ALITA ANJO DE COMBATE - HISTÓRIA COMPLETA DO MANGÁ vol 119 março 2025
-
8 ball pool black mod19 março 2025
-
World Map - Final Fantasy I Walkthrough19 março 2025
-
Star Comics MY HERO ACADEMIA Nr.619 março 2025