IJMS, Free Full-Text
Por um escritor misterioso
Last updated 14 março 2025

Forkhead Box L2 (FOXL2) is a member of the FOXL class of transcription factors, which are essential for ovarian differentiation and function. In the endometrium, FOXL2 is also thought to be important in cattle; however, it is not clear how its expression is regulated. The maternal recognition of pregnancy signal in cattle, interferon-Tau, does not regulate FOXL2 expression. Therefore, in the present study, we examined whether the ovarian steroid hormones that orchestrate implantation regulate FOXL2 gene expression in ruminants. In sheep, we confirmed that FOXL2 mRNA and protein was expressed in the endometrium across the oestrous cycle (day 4 to day 15 post-oestrus). Similar to the bovine endometrium, ovine FOXL2 endometrial expression was low during the luteal phase of the oestrous cycle (4 to 12 days post-oestrus) and at implantation (15 days post-oestrus) while mRNA and protein expression significantly increased during the luteolytic phase (day 15 post-oestrus in cycle). In pregnant ewes, inhibition of progesterone production by trilostane during the day 5 to 16 period prevented the rise in progesterone concentrations and led to a significant increase of FOXL2 expression in caruncles compared with the control group (1.4-fold, p < 0.05). Ovariectomized ewes or cows that were supplemented with exogenous progesterone for 12 days or 6 days, respectively, had lower endometrial FOXL2 expression compared with control ovariectomized females (sheep, mRNA, 1.8-fold; protein, 2.4-fold; cattle; mRNA, 2.2-fold; p < 0.05). Exogenous oestradiol treatments for 12 days in sheep or 2 days in cattle did not affect FOXL2 endometrial expression compared with control ovariectomized females, except at the protein level in both endometrial areas in the sheep. Moreover, treating bovine endometrial explants with exogenous progesterone for 48h reduced FOXL2 expression. Using in vitro assays with COS7 cells we also demonstrated that progesterone regulates the FOXL2 promoter activity through the progesterone receptor. Collectively, our findings imply that endometrial FOXL2 is, as a direct target of progesterone, involved in early pregnancy and implantation.

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text
Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS, Free Full-Text

IJMS Free Full-Text Research Advances In Mechanical, 52% OFF

IJMS, Free Full-Text

IJMS, Free Full-Text
Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS, Free Full-Text

IJMS Free Full-Text Immunoglobulin Abnormalities In Gaucher, 48% OFF

IJMS, Free Full-Text
Ijms Free Full Text Non Invasive Detection Of Extracellular Matrix

IJMS, Free Full-Text

Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm
Recomendado para você
-
Roqueiro Serguei morre aos 85 anos, no Rio de Janeiro14 março 2025
-
Incontrolável. Rock'n Rio - Volume 1: 978858442168814 março 2025
-
Canisso – Wikipédia, a enciclopédia livre14 março 2025
-
Frontiers Single-cell detection of primary transcripts, their14 março 2025
-
Banda Sinara apresenta o disco de estreia no Festival Bananada14 março 2025
-
Morte de Johnny Hallyday ocupa toda a imprensa francesa14 março 2025
-
98 of Kendall Jenner's Chicest Looks14 março 2025
-
Notch1 signaling enhances collagen expression and fibrosis in14 março 2025
-
Renato Russo: O Filho da Revoluçao: Marcelo, Carlos: 978852200907714 março 2025
-
Morre Serguei, o roqueiro brasileiro mais velho que o rock, aos 85 - 07/06/2019 - Ilustrada - Folha14 março 2025
você pode gostar
-
Triturador da sucata fabricante, comprar boa qualidade Triturador da sucata produtos da China14 março 2025
-
Jogo de Copos Nadir Brisa Long Drink com 6 Unidades - Super14 março 2025
-
rules - About the 3D chess they play on Star Trek - Chess Stack14 março 2025
-
Shu Kurenai icon14 março 2025
-
PSG vs Cerezo Osaka prediction, betting tips and best bets for14 março 2025
-
ArtStation - Pyramid head14 março 2025
-
Senran Kagura Reflexions – Review14 março 2025
-
Modern Warfare 3: what does it take to work on the world's biggest14 março 2025
-
BORUTO: NARUTO NEXT GENERATIONS Partner - Watch on Crunchyroll14 março 2025
-
Financial - Meios de Pagamento14 março 2025