IJMS, Free Full-Text
Por um escritor misterioso
Last updated 19 março 2025

Rheumatoid arthritis (RA) is a common disease worldwide and is treated commonly with methotrexate (MTX). CS12192 is a novel JAK3 inhibitor discovered by Chipscreen Biosciences for the treatment of autoimmune diseases. In the present study, we examined the therapeutic effect of CS12192 against RA and explored if the combinational therapy of CS12192 and MTX produced a synergistic effect against RA in rat collagen-induced arthritis (CIA). Arthritis was induced in male Sprague-Dawley rats by two intradermal injections of bovine type II collagen (CII) and treated with MTX, CS12192, or the combination of CS12192 and MTX daily for two weeks. Effects of different treatments on arthritis score, X-ray score, pathology, and expression of inflammatory cytokines and biomarkers were examined. We found that treatment with either CS12192 or MTX produced a comparable therapeutic effect on CIA including: (1) significantly lowering the arthritis score, X-ray score, serum levels of rheumatic factor (RF), C-reactive protein (CRP), and anti-nuclear antibodies (ANA); (2) largely alleviating histopathological damage, reducing infiltration of Th17 cells while promoting Treg cells; (3) inhibiting the expression of inflammatory cytokines and chemokines such as IL-1β, TNF-α, IL-6, CCL2, and CXCL1. All these inhibitory effects were further improved by the combinational therapy with MTX and CS12192. Of importance, the combinational treatment also resulted in a marked switching of the Th17 to Treg and the M1 to M2 immune responses in synovial tissues of CIA. Thus, when compared to the monotherapy, the combination treatment with CS12192 and MTX produces a better therapeutic effect against CIA with a greater suppressive effect on T cells and macrophage-mediated joint inflammation.

IJMS, Free Full-Text

IJMS, Free Full-Text
Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS, Free Full-Text

ISSN 1422-0067 (Online), International journal of molecular sciences
IJMS Free Full-Text Research Advances In Mechanical, 52% OFF

IJMS, Free Full-Text

IJMS, Free Full-Text
Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS, Free Full-Text

Ijms Free Full Text Abnormalities In Alternative 25056

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text
Recomendado para você
-
my reaction to MDPOPE! by Jazzystar123 on DeviantArt19 março 2025
-
mdpope TikTok19 março 2025
-
Americas Sickest Home Videos (DVD, 2011) for sale online19 março 2025
-
Aging of Atmospheric Brown Carbon Aerosol19 março 2025
-
Parte 2 ⚠️#mdpope, Mdpope 1 To 319 março 2025
-
The Waiting Shed on X: Most Disturbed Person on Planet Earth I and II This tweet is a marker that I'm finally done with the second one (over 3 hours long). Mostly19 março 2025
-
Stream Live 4 Internet Night.com OST - MDPOPE V2 Unfinished Leak by Josh Boss19 março 2025
-
God Screams Out - Single - Album by MDPOPE - Apple Music19 março 2025
-
God Dont Hear Dead Men - Single - Album by xanaji & MDPOPE - Apple19 março 2025
-
Very curious about these URLs with crazy domain names on Google19 março 2025
você pode gostar
-
Sources double down on counter strike source 2 rumors, with beta potentially coming this month — NeonLightsMedia19 março 2025
-
Ansioso em saber se conseguirá vaga no Sisu? Use nosso simulador - Guia do Estudante19 março 2025
-
Vergil Sparda Devil may cry, Dmc 5, Davil may cry19 março 2025
-
My Birds Laid Eggs19 março 2025
-
ShadowPlay: Record, Share Game Videos & Screenshots19 março 2025
-
Pixilart - Sonic EYX by Frog-lover19 março 2025
-
260+ Positive & Inspirational Quotes for Sunday Mornings - DIVEIN19 março 2025
-
The Addams Family Wednesday Addams Halloween Cosplay Costume19 março 2025
-
Kakashi, Naruto steam artwork19 março 2025
-
Papel De Parede Infantil Super Carros Corrida GT Jogos GG11519 março 2025