IJMS, Free Full-Text
Por um escritor misterioso
Last updated 25 março 2025

The firm integration of anterior cruciate ligament (ACL) grafts into bones remains the most demanding challenge in ACL reconstruction, since graft loosening means graft failure. For a functional-tissue-engineered ACL substitute to be realized in future, robust bone attachment sites (entheses) have to be re-established. The latter comprise four tissue compartments (ligament, non-calcified and calcified fibrocartilage, separated by the tidemark, bone) forming a histological and biomechanical gradient at the attachment interface between the ACL and bone. The ACL enthesis is surrounded by the synovium and exposed to the intra-articular micromilieu. This review will picture and explain the peculiarities of these synovioentheseal complexes at the femoral and tibial attachment sites based on published data. Using this, emerging tissue engineering (TE) strategies addressing them will be discussed. Several material composites (e.g., polycaprolactone and silk fibroin) and manufacturing techniques (e.g., three-dimensional-/bio-printing, electrospinning, braiding and embroidering) have been applied to create zonal cell carriers (bi- or triphasic scaffolds) mimicking the ACL enthesis tissue gradients with appropriate topological parameters for zones. Functionalized or bioactive materials (e.g., collagen, tricalcium phosphate, hydroxyapatite and bioactive glass (BG)) or growth factors (e.g., bone morphogenetic proteins [BMP]-2) have been integrated to achieve the zone-dependent differentiation of precursor cells. However, the ACL entheses comprise individual (loading history) asymmetric and polar histoarchitectures. They result from the unique biomechanical microenvironment of overlapping tensile, compressive and shear forces involved in enthesis formation, maturation and maintenance. This review should provide a road map of key parameters to be considered in future in ACL interface TE approaches.

Pat Testing Labels Template Unique Ijms Free Full Text Genome Editing In Agriculture - Best Templates Ideas, Best Tem…
IJMS - IJMS International Journal of Medical Students

IJMS, Free Full-Text

IJMS, Free Full-Text

Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS Free Full-Text Immunoglobulin Abnormalities In Gaucher, 48% OFF

IJMS, Free Full-Text

IJMS, Free Full-Text

Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm

IJMS, Free Full-Text
Recomendado para você
-
Where is the best place to farm Spider Silk? - TibiaQA25 março 2025
-
The common spiders of the United States. Spiders. THE CINIFL(3NID25 março 2025
-
A)Sketch of a spider leg showing all segments: joints without25 março 2025
-
Loading of the tibia–metatarsus joint of the hunting spider25 março 2025
-
What can be considered as oldschool decoration? - TibiaQA25 março 2025
-
Spider Anatomy Flashcards25 março 2025
-
Silk fibroin scaffolds for common cartilage injuries25 março 2025
-
25 Years of Tibia Quest - Tiblioteca25 março 2025
-
Task:Oramond Citizen - Tibia Wiki25 março 2025
-
Just came back to this game after 10 years. Fortress overran by Giant Wrens. 10/10, would buy again. : r/dwarffortress25 março 2025
você pode gostar
-
Moto de Ferro Trilha Miniatura Yamaha yz 250 1:6 na Caixa New-Ray em Promoção na Americanas25 março 2025
-
Home25 março 2025
-
Coco Chanel & Igor Stravinsky Movie Posters From Movie Poster Shop25 março 2025
-
PRO EVOLUTION SOCCER 2012 PC GAME FREE DOWNLOAD 6.4 GB Pro Evolution Soccer 2012 PC Game Free Download Pro Ev…25 março 2025
-
Desenho de desenho kawaii fofo pintado e colorido por Usuário não registrado o dia 26 de Fevereiro do 202125 março 2025
-
codes for grand sea pirate idle|TikTok Search25 março 2025
-
As pessoas colocam as mulheres sempre Ezequias Clarindo - Pensador25 março 2025
-
NvZT2 Art - Hellish Fighter by FazeTheEggCarUndead2 on DeviantArt25 março 2025
-
Reddit - Dive into anything25 março 2025
-
The Super Mario Bros. Movie on X: Let's get the show on the 🌈 road #SuperMarioMovie / X25 março 2025