Competition between Serum IgG, IgM, and IgA Anti-Glycan Antibodies
Por um escritor misterioso
Last updated 26 março 2025
Anti-glycan antibodies are an abundant subpopulation of serum antibodies with critical functions in many immune processes. Changes in the levels of these antibodies can occur with the onset of disease, exposure to pathogens, or vaccination. As a result, there has been significant interest in exploiting anti-glycan antibodies as biomarkers for many diseases. Serum contains a mixture of anti-glycan antibodies that can recognize the same antigen, and competition for binding can potentially influence the detection of antibody subpopulations that are more relevant to disease processes. The most abundant antibody isotypes in serum are IgG, IgM, and IgA, but little is known regarding how these different isotypes compete for the same glycan antigen. In this study, we developed a multiplexed glycan microarray assay and applied it to evaluate how different isotypes of anti-glycan antibodies (IgA, IgG, and IgM) compete for printed glycan antigens. While IgG and IgA antibodies typically outcompete IgM for peptide or protein antigens, we found that IgM outcompete IgG and IgA for many glycan antigens. To illustrate the importance of this effect, we provide evidence that IgM competition can account for the unexpected observation that IgG of certain antigen specificities appear to be preferentially transported from mothers to fetuses. We demonstrate that IgM in maternal sera compete with IgG resulting in lower than expected IgG signals. Since cord blood contains very low levels of IgM, competition only affects maternal IgG signals, making it appear as though certain IgG antibodies are higher in cord blood than matched maternal blood. Taken together, the results highlight the importance of competition for studies involving anti-glycan antibodies.

Frontiers Glyco engineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues

Frontiers Comparative Glycomics of Immunoglobulin A and G From Saliva and Plasma Reveals Biomarker Potential

Frontiers Immunoglobulin M in Health and Diseases: How Far Have We Come and What Next?

Dynamics of antibodies to SARS‐CoV‐2 in convalescent plasma donors - Steenhuis - 2021 - Clinical & Translational Immunology - Wiley Online Library

Serum components influence antibody reactivity to glycan and DNA antigens

Antibodies, Free Full-Text

Serum components influence antibody reactivity to glycan and DNA antigens

Types of antibodies MBL Life Sience -ASIA

Emergence and significance of carbohydrate-specific antibodies

Antibodies, Free Full-Text

Antibodies, Free Full-Text

Frontiers IgA and FcαRI: Pathological Roles and Therapeutic Opportunities

Emergence and significance of carbohydrate-specific antibodies
Recomendado para você
-
Shotgun King: The Final Checkmate Free Download (v1.39c) « IGGGAMES26 março 2025
-
Microarray assessment of N-glycan-specific IgE and IgG profiles26 março 2025
-
Development of a Multiplex Glycan Microarray Assay and Comparative26 março 2025
-
Altered Fc galactosylation in IgG4 is a potential serum marker for26 março 2025
-
The systemic anti-microbiota IgG repertoire can identify gut26 março 2025
-
Optimization of an Experimental Vaccine To Prevent Escherichia26 março 2025
-
BEST New Nintendo Switch Games26 março 2025
-
Castle Clash, Character catalogue Wiki26 março 2025
-
Quantitative Recoveries of Exosomes and Monoclonal Antibodies from26 março 2025
-
22 Carbines for Home Defense – Home Defense Journal26 março 2025
você pode gostar
-
Sonic Frontiers is already the best game in the saga, according to Metacritic users26 março 2025
-
Modern Warfare 2 disc only contains 70MB of data26 março 2025
-
Atos - Igarapé Grande,Maranhão: Estutande de Educação física Bacharel - fazendo anamnese básico para alunos iniciantes e como personal trainer (MA)26 março 2025
-
Idle Sloth💙💛 on X: Brothers: A Tale of Two Sons Remake #TheGameAwards Guide two brothers on an epic fairy tale journey of discovery, loss, adventure and mystery in Brothers: A Tale of26 março 2025
-
Oblee Marketplace Quadros Para Salão de Beleza Cabeleireira26 março 2025
-
Bebê Reborn Boneca Morena Roupa Pagão Toda Vinil Silicone26 março 2025
-
Russian Doomer Music vol.3 (Superior) - playlist by bartas455026 março 2025
-
Mundial de Jiu-Jitsu 2021 é confirmado para dezembro – Sensō Jiu Jitsu26 março 2025
-
Indicação de Anime: Magi: The Labyrinth of Magic26 março 2025
-
Ficheiro:Grand Theft Auto San Andreas capa.png – Wikipédia, a enciclopédia livre26 março 2025