Cells, Free Full-Text

Immunometabolism is an emerging discipline in cancer immunotherapy. Tumor tissues are heterogeneous and influenced by metabolic reprogramming of the tumor immune microenvironment (TIME). In the TIME, multiple cell types interact, and the tumor and immune cells compete for limited nutrients, resulting in altered anticancer immunity. Therefore, metabolic reprogramming of individual cell types may influence the outcomes of immunotherapy. Understanding the metabolic competition for access to limited nutrients between tumor cells and immune cells could reveal the breadth and complexity of the TIME and aid in developing novel therapeutic approaches for cancer. In this review, we highlight that, when cells compete for nutrients, the prevailing cell type gains certain advantages over other cell types; for instance, if tumor cells prevail against immune cells for nutrients, the former gains immune resistance. Thus, a strategy is needed to selectively suppress such resistant tumor cells. Although challenging, the concept of cell type-specific metabolic pathway inhibition is a potent new strategy in anticancer immunotherapy.

JTurkGerGynecolAssoc on X: Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study You can see the free full text of

Cells, Free Full-Text

Full-spectrum cell-free RAN for 6G systems: s

Cancers, Free Full-Text

Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living - ScienceDirect

Cell-free expression and synthesis of viruses and bacteriophages: applications to medicine and nanotechnology - ScienceDirect

Cell-free Macromolecular Synthesis

Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods, Microbial Cell Factories

Remote immune processes revealed by immune-derived circulating cell-free DNA

Nt Novo Cella Get File - Colaboratory