Cells, Free Full-Text

Por um escritor misterioso
Last updated 19 março 2025
Cells, Free Full-Text
Cancer stem cells play a crucial role in tumor initiation, metastasis, and resistance to treatment. Cellular heterogeneity and plasticity complicate the isolation of cancer stem cells. The impact of intra-tumor cellular heterogeneity using a label-free approach remains understudied in the context of treatment resistance. Here, we use the sedimentation field–flow fractionation technique to separate, without labeling, cell subpopulations of colorectal cancer cell lines and primary cultures according to their biophysical properties. One of the three sorted cell subpopulations exhibits characteristics of cancer stem cells, including high tumorigenicity in vivo and a higher frequency of tumor-initiating cells compared to the other subpopulations. Due to its chemoresistance, two- and three-dimensional in vitro chemosensitivity assays highlight the therapeutic relevance of this cancer stem cell subpopulation. Thus, our results reveal the major implication of intra-tumor cellular heterogeneity, including cancer stem cells in treatment resistance, thanks to our label-free cell sorting approach. This approach enables—by breaking down the tumor—the study the individualized response of each sorted tumor cell subpopulation and to identify chemoresistance, thus offering new perspectives for personalized therapy.
Cells, Free Full-Text
Electrochemical characterization of anode‐free K‐metal full‐cells
Cells, Free Full-Text
Advances and applications of cell-free systems for metabolic
Cells, Free Full-Text
Harnessing Extracellular Vesicles for Regenerative Therapy
Cells, Free Full-Text
Effect of calendar ageing on the cycle life of anode-free full
Cells, Free Full-Text
Frontiers Combining Cell-Free Protein Synthesis and NMR Into a
Cells, Free Full-Text
Anomalous Scaling of Gene Expression in Confined Cell-Free
Cells, Free Full-Text
Rapid cell-free forward engineering of novel genetic ring
Cells, Free Full-Text
Cell-free synthesis of human interferon. - Abstract - Europe PMC
Cells, Free Full-Text
Five-Year Outcomes for Refractory B-Cell Lymphomas with CAR T-Cell
Cells, Free Full-Text
Cell-free synthetic biology: Engineering in an open world
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
An integrated in vivo/in vitro framework to enhance cell-free
Cells, Free Full-Text
Remote immune processes revealed by immune-derived circulating
Cells, Free Full-Text
Antibodies, Free Full-Text

© 2014-2025 praharacademy.in. All rights reserved.