Cancers, Free Full-Text
Por um escritor misterioso
Last updated 16 junho 2024
![Cancers, Free Full-Text](https://pub.mdpi-res.com/cancers/cancers-14-00976/article_deploy/html/images/cancers-14-00976-g001.png?1645093936)
Emerging evidence suggests that a small subpopulation of cancer stem cells (CSCs) is responsible for initiation, progression, and metastasis cascade in tumors. CSCs share characteristics with normal stem cells, i.e., self-renewal and differentiation potential, suggesting that they can drive cancer progression. Consequently, targeting CSCs to prevent tumor growth or regrowth might offer a chance to lead the fight against cancer. CSCs create their niche, a specific area within tissue with a unique microenvironment that sustains their vital functions. Interactions between CSCs and their niches play a critical role in regulating CSCs’ self-renewal and tumorigenesis. Differences observed in the frequency of CSCs, due to the phenotypic plasticity of many cancer cells, remain a challenge in cancer therapeutics, since CSCs can modulate their transcriptional activities into a more stem-like state to protect themselves from destruction. This plasticity represents an essential step for future therapeutic approaches. Regarding self-renewal, CSCs are modulated by the same molecular pathways found in normal stem cells, such as Wnt/β-catenin signaling, Notch signaling, and Hedgehog signaling. Another key characteristic of CSCs is their resistance to standard chemotherapy and radiotherapy treatments, due to their capacity to rest in a quiescent state. This review will analyze the primary mechanisms involved in CSC tumorigenesis, with particular attention to the roles of CSCs in tumor progression in benign and malignant diseases; and will examine future perspectives on the identification of new markers to better control tumorigenesis, as well as dissecting the metastasis process.
![Cancers, Free Full-Text](https://www.osfhealthcare.org/blog/wp-content/uploads/2022/08/ONC-Consideration-Cancer-Warning-Signs-1080x1080-FIN.png)
Know the signs of cancer to catch it early
![Cancers, Free Full-Text](https://www.lungcancerjournal.info/cms/asset/atypon:cms:attachment:img:d327e6:rev:1702088314572-29361:pii:S0169500223X00117/cover.tif.jpg)
Home Page: Lung Cancer
![Cancers, Free Full-Text](https://www.mdpi.com/cancers/cancers-05-01469/article_deploy/html/images/cancers-05-01469-g003-1024.png)
Cancers, Free Full-Text
CA: A Cancer Journal for Clinicians - Wiley Online Library
![Cancers, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2005/nejm_2005.353.issue-16/nejmoa052306/production/images/img_medium/nejmoa052306_f1.jpeg)
Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer
![Cancers, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2022/nejm_2022.386.issue-21/nejmoa2202170/20220523/images/img_small/nejmoa2202170_f0.jpeg)
Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer
![Cancers, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2007/nejm_2007.357.issue-15/nejmoa071167/production/images/img_medium/nejmoa071167_f1.jpeg)
HER2 and Response to Paclitaxel in Node-Positive Breast Cancer
![Cancers, Free Full-Text](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-023-41774-w/MediaObjects/41467_2023_41774_Fig1_HTML.png)
Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization
![Cancers, Free Full-Text](https://www.eu-focus.europeanurology.com/cms/attachment/2114859110/2084630400/gr1.jpg)
Emerging Utility of Urinary Cell-free Nucleic Acid Biomarkers for Prostate, Bladder, and Renal Cancers - European Urology Focus
![Cancers, Free Full-Text](https://pub.mdpi-res.com/cancers/cancers-02-00824/article_deploy/html/images/cancers-02-00824-g001-1024.png?1401474976)
Cancers, Free Full-Text
![Cancers, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2012/nejm_2012.366.issue-26/nejmoa1200690/20161118/images/img_medium/nejmoa1200690_f1.jpeg)
Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
![Cancers, Free Full-Text](https://pub.mdpi-res.com/cancers/cancers-02-00752/article_deploy/html/images/cancers-02-00752-g001-1024.png?1401472481)
Cancers, Free Full-Text
![Cancers, Free Full-Text](https://i1.rgstatic.net/publication/262789223_Predictors_of_recurrence_free_survival_for_patients_with_stage_II_and_III_colon_cancer/links/55915fe308ae47a349109c94/largepreview.png)
PDF) Predictors of recurrence free survival for patients with stage II and III colon cancer
![Cancers, Free Full-Text](https://www.mdpi.com/cancers/cancers-02-02084/article_deploy/html/images/cancers-02-02084-g001-1024.png)
Cancers, Free Full-Text
Recomendado para você
-
Hana Hana no Mi, Wiki16 junho 2024
-
Ushi Ushi no Mi, Model: Giraffe, One Piece Wiki16 junho 2024
-
How do you imagine an awakening of these Devil Fruits? : r/OnePiece16 junho 2024
-
Nico Robin has already Awakened her Devil Fruit! - One Piece16 junho 2024
-
Paramecia Classification and possible Awakenings [Minor Anime Spoilers] : r/OnePiece16 junho 2024
-
Nico Robin has the potential to be one of the strongest of the Straw Hats because of her Devil Fruit : r/OnePiece16 junho 2024
-
ALOHA COTTAGES - Prices & Guest house Reviews (Maui, Hawaii)16 junho 2024
-
Strongest Devil Fruit Abilities In One Piece Manga16 junho 2024
-
In One Piece, which Devil Fruits are better than Magu Magu no Mi? - Quora16 junho 2024
-
Powers & Abilities - Hana Hana no Mi - Nico Robin's power development16 junho 2024
você pode gostar
-
Roblox e mais jogos ajudam psicólogos a tratar ansiedade em crianças – Tecnoblog16 junho 2024
-
Série Evil - Contatos Sobrenaturais 2ª Temporada16 junho 2024
-
LIDI “ PÊNALTI “ OU “ TIRO LIVRE DIRETO “ ? QUAIS AS DIFERENÇAS16 junho 2024
-
burro-em-pé Dicionário Infopédia da Língua Portuguesa16 junho 2024
-
NEW* All Working Roblox Anime Dimensions Codes 2023 March! Anime Dimensions Simulator - GAME GARDEN16 junho 2024
-
TOP 10 BEST Dinner Movie Theater near King of Prussia, PA16 junho 2024
-
Double Dragon Advance - VGMdb16 junho 2024
-
Kamisama no Iutoori 2 (As the Gods Will: The Second Series)16 junho 2024
-
Yofukashi no Uta Capítulo 82 – Mangás Chan16 junho 2024
-
How did winning Valkyrie do this : r/Beyblade16 junho 2024