Biomedicines, Free Full-Text
Por um escritor misterioso
Last updated 20 março 2025

Infections are important factors contributing to the morbidity and mortality among elderly patients. High rates of consumption of antimicrobial agents by the elderly may result in increased risk of toxic reactions, deteriorating functions of various organs and systems and leading to the prolongation of hospital stay, admission to the intensive care unit, disability, and lethal outcome. Both safety and efficacy of antibiotics are determined by the values of their plasma concentrations, widely affected by physiologic and pathologic age-related changes specific for the elderly population. Drug absorption, distribution, metabolism, and excretion are altered in different extents depending on functional and morphological changes in the cardiovascular system, gastrointestinal tract, liver, and kidneys. Water and fat content, skeletal muscle mass, nutritional status, use of concomitant drugs are other determinants of pharmacokinetics changes observed in the elderly. The choice of a proper dosing regimen is essential to provide effective and safe antibiotic therapy in terms of attainment of certain pharmacodynamic targets. The objective of this review is to perform a structure of evidence on the age-related changes contributing to the alteration of pharmacokinetic parameters in the elderly.

Biomedicines, Free Full-Text
NMR in Biomedicine - Wiley Online Library

Archives Biomedicine

Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication: Molecular Therapy - Methods & Clinical Development

Open Access Journal of Biomedical Science

NMR in Biomedicine - Wiley Online Library

Biomedicines An Open Access Journal from MDPI

Biomedicines, Free Full-Text

Gut microbiota and its metabolites in depression: from pathogenesis to treatment - eBioMedicine
Recomendado para você
-
partida 9 playok20 março 2025
-
Torneios, Mancala World20 março 2025
-
prefeitura do municÃpio de itapetininga - sp - Prefeitura Municipal de20 março 2025
-
Trap in the opening! Win a piece in checkers! #warcaby #checkers #drau20 março 2025
-
Generative Models for Synthetic Urban Mobility Data: A Systematic Literature Review20 março 2025
-
tra maging kriminal for pc = D : r/NANIKPosting20 março 2025
-
Carol Dondorfer-Yontek Obituary (1945 - 2023) - Concord, OH - News-Herald20 março 2025
-
Collections Musée d'art et d'histoire du Judaïsme20 março 2025
-
2007 ACR/ARHP Scientific Meeting Program Book - American20 março 2025
-
CASTLE IN KÓRNIK ***20 março 2025
você pode gostar
-
LoL: YoDa, um dos maiores streamers do cenário brasileiro20 março 2025
-
fofos casal anime20 março 2025
-
Xbox 360 Lot 5 Games: Injustice: Gods Among Us, Skyrim20 março 2025
-
Estratégia britânica de xadrez: Jogue como o campeão xadrez Howard Staunton (Paperback)20 março 2025
-
Digimon Ghost Game - Ending Theme #3 🎤: Bye-Bye-Hand Now20 março 2025
-
Stickman Home Escape - Online Game - Play for Free20 março 2025
-
Karate King vs Kung Fu Master - Kung Fu Attack 3 para Android20 março 2025
-
The Smurfs Tales #6: Smurf and Order and Other Tales - Papercutz20 março 2025
-
Filmes de Universos Alternativos - Grupo20 março 2025
-
Buy Far Cry 2 PC Ubisoft Official Store20 março 2025