Biology, Free Full-Text
Por um escritor misterioso
Last updated 19 março 2025

In addition to representing a significant part of the natural background radiation exposure, α-particles are thought to be a powerful tool for targeted radiotherapy treatments. Understanding the molecular mechanisms of recognition, signaling, and repair of α-particle-induced DNA damage is not only important in assessing the risk associated with human exposure, but can also potentially help in identifying ways of improving the efficacy of radiation treatment. α-particles (He2+ ions), as well as other types of ionizing radiation, and can cause a wide variety of DNA lesions, including DNA double-strand breaks (DSBs). In mammalian cells, DNA DSBs can be repaired by two major pathways: non-homologous end-joining (NHEJ) and homologous recombination (HR). Here, we investigated their dynamics in mouse NIH-3T3 cells through the recruitment of key proteins, such as the KU heterodimer for NHEJ and RAD51 for HR upon localized α-particle irradiation. To deliver α-particles, we used the MIRCOM microbeam, which allows targeting of subnuclear structures with submicron accuracy. Using mouse NIH-3T3 cells, we found that the KU heterodimer is recruited much earlier at DNA damage sites marked by H2AX phosphorylation than RAD51. We also observed that the difference in the response of the KU complex and RAD51 is not only in terms of time, but also in function of the chromatin nature. The use of a microbeam such as MIRCOM, represents a powerful tool to study more precisely the cellular response to ionizing irradiation in a spatiotemporal fashion at the molecular level.

Cells Penworthy Prebound Books

DOC) Well-cited publications and their citation: biology, environmental science (10 examples); cited in China, France, Spain, Germany, Russia, U.S., India, Poland, according to Microsoft Academic; links to full texts free;

Expanding biological applications using cell-free metabolic engineering: An overview - ScienceDirect

Books - The Berkeley Review

Advancing MDS Nursing Course 1: Biology, diagnosis and management

Biology, Free Full-Text

QuickStudy Biology Grade Booster Pack ( 9781423244073)

Soc Eds Befehls-Shell Herunterladen - Colaboratory
Biology the easy way : Edwards, Gabrielle I : Free Download, Borrow, and Streaming : Internet Archive

Bold biology font Royalty Free Vector Image - VectorStock

A primer on emerging field-deployable synthetic biology tools for global water quality monitoring
Recomendado para você
-
Smart TV Club APK for Android Download19 março 2025
-
Download do APK de SMART CLUB para Android19 março 2025
-
Chapter 2 - Planning for Smart Growth, Guide for Integrating Goods and Services Movement by Commercial Vehicles in Smart Growth Environments19 março 2025
-
New 3.1.0 Update on Android! you can now choose a profile pic among other features : r/MeChat19 março 2025
-
Remote Sensing, Free Full-Text19 março 2025
-
IJERPH, Free Full-Text19 março 2025
-
CApp Smart APK for Android Download19 março 2025
-
Scale‐dependent effects of marine subsidies on the island biogeographic patterns of plants - Obrist - 2022 - Ecology and Evolution - Wiley Online Library19 março 2025
-
Magento 2 Layered Navigation Extension, Ajax Filter for Improved Layered Navigation, Custom Product Collection, Horizontal Category Filter19 março 2025
-
Ask Ai Kids Club on the App Store19 março 2025
você pode gostar
-
Jogo de Tabuleiro Xadrez 32 Peças Pangué19 março 2025
-
Brasil exporta carne de cavalo19 março 2025
-
Delay ou Front Fill Ultra Compact 8″ Passivo DB Tecnologia Acustica – Masterdb19 março 2025
-
Plants Vs. Zombies: Battle For Neighborville on PS4 — price history, screenshots, discounts • USA19 março 2025
-
eBooks Kindle: Tabuleiro da vida: o xadrez na história, Carvalho, Hebert19 março 2025
-
Página para colorir de carros antigos19 março 2025
-
Road To Ninja is definitely the best Naruto movie, and this scene is one of the reasons why. : r/Naruto19 março 2025
-
CÓMO VOLAR EN BROOKHAVEN HACKS Y TRUCOS SECRETOS en Brookhaven rp Roblox19 março 2025
-
JUJUTSU KAISEN Season 2 - Prime Video19 março 2025
-
14 best Fairy-type Pokemon ranked: Togekiss, Sylveon, Zacian19 março 2025