Is Android 16 the main antagonist of Dragon Ball FighterZ's story? Why this is interesting considering his backstory

It was revealed recently that Dragon Ball FighterZ's "What If" story mode was to feature Android 16 going after the heroes of the Dragon Ball franchise. If that means that Android 16 is to be the main antagonist of

Android 16, Dragon Ball Wiki

Is Android 16 the main antagonist of Dragon Ball FighterZ's story

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Can someone explain what the deal is with 21 is to me? Is 16 her