Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H
Por um escritor misterioso
Last updated 20 junho 2024
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://www.biorxiv.org/content/biorxiv/early/2022/01/22/2022.01.20.477077/F6.large.jpg)
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://ars.els-cdn.com/content/image/1-s2.0-S0969996113000983-fx1.jpg)
Silencing of the Charcot–Marie–Tooth disease-associated gene GDAP1
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fnm.3664/MediaObjects/41591_2014_Article_BFnm3664_Fig3_HTML.jpg)
Soluble neuregulin-1 modulates disease pathogenesis in rodent
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://www.researchgate.net/publication/223970447/figure/fig5/AS:279166688743434@1443569933203/Enhanced-AKT-activity-and-unaltered-expression-levels-of-Dlg1-and-Par-3AImmunostaining.png)
Enhanced AKT activity and unaltered expression levels of Dlg1 and
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs12035-022-02838-y/MediaObjects/12035_2022_2838_Figa_HTML.png)
Treatment with IFB-088 Improves Neuropathy in CMT1A and CMT1B Mice
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://www.cmttreatmentreport.com/wp-content/uploads/cmttreatmentreport-website-screenshot-2020.png)
CMT Treatment Report
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://www.researchgate.net/publication/330498637/figure/fig2/AS:718586989510664@1548335897469/MFN2-R94Q-affects-neuronal-ER-mitochondria-contacts-in-vitro-and-in-vivo-A.png)
MFN2 R94Q affects neuronal ER-mitochondria contacts in vitro and
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://i1.rgstatic.net/publication/289501300_Dysregulation_of_ErbB_Receptor_Trafficking_and_Signaling_in_Demyelinating_Charcot-Marie-Tooth_Disease/links/5fc1d95d458515b7977c459d/largepreview.png)
Dysregulation of ErbB Receptor Trafficking and Signaling in
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fnm.3664/MediaObjects/41591_2014_Article_BFnm3664_Fig2_HTML.jpg)
Soluble neuregulin-1 modulates disease pathogenesis in rodent
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41467-019-12909-9/MediaObjects/41467_2019_12909_Fig1_HTML.png)
Transcriptional dysregulation by a nucleus-localized aminoacyl
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://www.researchgate.net/publication/223970447/figure/fig4/AS:279117355339834@1443558171975/Quantitative-and-ultrastructural-analysis-of-abnormal-axon-Schwann-cell-unitsAWhen.png)
Quantitative and ultrastructural analysis of abnormal axon/Schwann
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://www.researchgate.net/publication/309617961/figure/fig1/AS:432411382161412@1480106315214/Figure-EV2-Expression-levels-of-Nrg1-and-phosphorylation-of-Erk-and-Akt-in-Mtmr2-A-A.png)
Figure EV2. Expression levels of Nrg1 and phosphorylation of Erk
![Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H](https://www.researchgate.net/profile/Luca-Bartesaghi-2/publication/330498637/figure/fig3/AS:718586989531146@1548335897545/MFN2-R94Q-induces-ER-stress-both-in-vitro-and-in-vivo-A-Immunoquantification-of-level.png)
MFN2 R94Q induces ER stress both in vitro and in vivo. (A
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